TP53/RARA

Two Color, Enumeration Probe

Ref: 14-015

The TP53/RARA DNA-FISH Probe is designed to detect the deletion of the TP53 gene located on 17p13, relative to the control marker gene RARA located on 17q21, using fluorescence in situ hybridization (FISH). The TP53 gene is a known tumor suppressor gene and is frequently deleted in a wide variety of solid tumors [1, 2] and hematologic malignancies such as mature B-cell neoplasms,[3] myeloid disorders such as acute myeloid leukemia (AML),[4] and myelodysplastic syndrome (MDS).[5]  Deletion of the TP53 gene has been associated with advanced stage, shortened survival, and resistance to treatment in several malignancies and solid tumors.[3,6]   The loss of TP53 is also found in chronic lymphocytic leukemia (CLL) cases and is associated with a very poor clinical outcome.[7,8]

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<em>TP53</em>/<em>RARA</em> DNA Probes