Two Color, Enumeration Probe

Ref: 27-014

The RB1/D13S1009 DNA-FISH Probe is designed to detect loss of the RB1 gene on chromosome 13q14 relative to the control marker, D13S1009 on chromosome 13q34, using fluorescence in situ hybridization (FISH).  The RB1 gene is a well characterized tumor-suppressor gene and bi-allelic inactivation of the gene due to mutations and/or deletions is causal for the development of Retinoblastoma (RB).  Deletion of the RB1 gene is also common in a wide variety of solid tumors and hematologic malignancies such as chronic lymphocytic leukemia (CLL), multiple myeloma (MM), acute myelocytic leukemia (AML), myelodysplastic syndrome (MDS), and chronic myeloproliferative disorders.[1-3]  The RB1 gene is proximal to the D13S25 locus at 13q14, which is often co-deleted with the RB1 gene in some B-cell hematologic malignancies.

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<em>RB1</em>/D13S1009 DNA Probes