PML/RARA

Two Color, Two Fusion Translocation Probe

Ref: 12-008

The PML/RARA DNA-FISH Probe is designed to detect the translocation between the PML gene on chromosome 15q24 (previously assigned to band 15q22) and the RARA gene on chromosome 17q21, using fluorescence in situ hybridization (FISH).  The t(15;17) translocation is the diagnostic hallmark of acute promyelocytic leukemia (APL), a sub-group of acute myelogenous leukemia (AML), and results in the fusion of the PML and RARA genes.[1]  The presence of a PML-RARA fusion predicts a favorable response to differentiation therapy with all-trans retinoic acid (ATRA) and is currently the most curable subtype of acute myeloid leukemia (AML).[1-3]  The  t(15;17) translocation has also been identified in chronic myeloid leukemia (CML) cases with promyelocytic blast crisis.

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<em>PML</em>/<em>RARA</em> DNA Probes