MYH11/CBFB
Two Color, Two Fusion Translocation Probe
Ref: 12-010
The MYH11/CBFB DNA-FISH Probe is designed to detect the pericentric inversion of chromosome 16 (inv(16)(p13q22) and t(16;16)(p13;q22) involving the MYH11 gene on 16p13 and the CBFB gene on 16q22 using fluorescence in situ hybridization (FISH). The rearrangement of the MYH11 and CBFB gene results in a fusion of both genes. The inv(16) abnormality is found in ~5 – 8% of all of de novo acute myeloid leukemia (AML) cases and is associated with AML-M4eo subtype (based on FAB classification).[1,2] Inv(16) and t(16;16) has also been observed in therapy related myelodysplastic syndrome (t-MDS) cases and in eosinophilic blast crisis of chronic myelogenous leukemia (CML) cases.[2] Whether alone or as part of a complex patient karyotype, inv(16) is indicative of a good prognosis in AML cases.[3]
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