Two Color, Two Fusion Translocation Probe

Ref: 13-004

The IGH/MYC DNA-FISH Probe is designed to detect the translocation between the MYC gene located at 8q24 and the IGH gene located at 14q32, using fluorescence in situ hybridization (FISH).  The translocation between the MYC and IGH gene is designated as t(8;14)(q24;q32) and is the cytogenetic hallmark of Burkitt lymphoma (BL), which is found in 75-85% of patients.[1]  In BL, t(8;14)(q24;q32) is associated with an aggressive clinical course that responds well to high-intensity, brief-duration drug regimens with an overall favorable outcome.[1,2]  This rearrangement has been observed at lower frequencies in other non-Hodgkin lymphomas (NHLs), such as diffuse large B-cell lymphoma (DLBCL) (<10%).[3,4]  t(8;14) also occurs less frequently in acute lymphoblastic leukemia (ALL) where it has been associated with an unfavorable outcome.[3,5]

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<em>MYC</em>/<em>IGH</em> DNA Probes