MYC Break Apart

Two Color, Break Apart Probe

Ref: 13-008

The MYC Break Apart DNA-FISH Probe is designed to detect the translocation between the MYC gene located at 8q24 and one of 11 known translocation partner loci using fluorescence in situ hybridization (FISH).  The most common translocation, t(8;14)(q24;q32), is found in 75-85% of Burkitt lymphoma (BL) cases and is the cytogenetic hallmark of BL.[1,2]  The t(8;14)(q24;q32) in BL is associated with an aggressive clinical course that responds well to high-intensity, brief-duration drug regimens with an overall favorable outcome.[2,3]  Translocation of MYC is often detected as a secondary genomic abnormality at low frequencies in high-grade B-cell lymphomas, such as diffuse large B-cell lymphoma (DLBCL) (5-16%) and chronic lymphocytic leukemia (CLL) (0.1-2%).[1,3-5]  In DLBCL, the presence of MYC translocation is associated with an aggressive disease with a poor prognosis and an unfavorable outcome.[4]  MYC translocation has also been observed in 4-6% of acute lymphoblastic leukemia (ALL).[6]

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<em>MYC</em> Break Apart DNA Probes