Two Color, Enumeration Probe

Ref: 14-016

The MYB/SHGC-79576 DNA-FISH Probe is designed to detect copy number changes of the MYB locus located on 6q23 relative to a 6p12 control locus, using fluorescence in situ hybridization (FISH).[1]  MYB gene is involved in duplications, translocation, and deletions in a variety of cancer types. Loss of MYB has been observed in ~5% of chronic lymphocytic leukemia (CLL) cases[2] and has been associated with a poor prognosis in CLL cases.[2]  In breast tumors, the gain of the MYB gene has been observed in ~ 30% of hereditary BRCA1 positive breast tumors.[3]

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<em>MYB</em>/SHGC-79576 DNA Probes