Two Color, Two Fusion Translocation Probe

Ref: 17-004

The IGH/MALT1 DNA-FISH probe is designed to detect the translocation between the IGH gene located at 14q32 and the MALT1 gene located at 18q21 by fluorescence in situ hybridization (FISH), designated as t(14;18)(q32;q21).  The rearrangement of IGH/MALT1 has been observed in 10-20% of mucosa-associated lymphoid tissue (MALT) lymphoma, predominantly occurring in liver, skin, and ocular adnexa.[1-3]  By conventional cytogenetics, t(14;18)(q32;q21) involving the IGH and MALT1 genes is indistinguishable from the t(14;18)(q32;q21) involving the IGH and BCL2 genes (the hallmark of follicular lymphoma).  These translocations can be distinguished by FISH, using the respective DNA-FISH probes.

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<em>IGH</em>/<em>MALT1</em> DNA Probes