Two Color, Two Fusion Translocation Probe

Ref: 16-005

The IGH/FGFR3 translocation probe is designed to detect the translocation between the FGFR3 gene located on 4p16 and the IGH gene located on 14q32 using fluorescence in situ hybridization (FISH).  Rearrangement of the FGFR3 and IGH genes is desginated as t(4;14) and it has been observed in ~15% of multiple myeloma (MM) patients.  Detection of the t(4;14) translocation is clinically relevant because it confers an aggressive phenotype with a poor prognosis and a rapid relapse after high-dose chemotherapy.[1-3]

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<em>FGFR3</em>/<em>IGH</em> DNA Probes