ERBB2/Cen17

Two Color, Enumeration Probe

Ref: 22-003

The ERBB2/Cen17 DNA-FISH Probe is designed to detect the amplification of the ERBB2 gene (also named HER2/neu) on chromosome 17q12 relative to the control Cen17 using fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded (FFPE) breast cancer tissues.  Overexpression of the ERBB2 gene occurs in 25-30% of human breast carcinomas, and ~90-95% of these cases result directly from gene amplification.[1]  Patients showing such an amplification are at high-risk for relapse and lower overall survival.[1-3]  Amplification of the ERBB2 gene predicts a favorable response to certain chemotherapy regimens and selective monoclonal antibody therapy with trastuzumab.[1-5]  ERBB2 amplification is also seen in other solid tumors such as gastric, esophageal, gynecologic, bladder, and non-small cell lung cancer and correlates with a poor prognosis.[6]

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<em>ERBB2</em>/Cen17 DNA Probes