Two Color, Enumeration Probe

Ref: 11-004

The EGR1/5p15 DNA-FISH Probe is designed to detect the deletion of the EGR1 gene located on 5q31 relative to the control locus 5p15 by fluorescence in situ hybridization (FISH).  The deletion of the EGR1 gene is detected in 10-15% of de novo myelodyplastic syndrome (MDS) and acute myeloid leukemia (AML) patients, and in 35-42% of therapy-related MDS (t-MDS) and therapy-related AML (t-AML) patients.[1, 2]  When observed as the sole chromosomal aberration in cases of MDS (also called 5q-syndrome), deletion of the EGR1 gene is associated with a favorable prognosis and good response to lenalidomide treatment.[3]  In cases of MDS/AML and t-MDS/t-AML, deletion of EGR1 as part of a complex karyotype is associated with a worse prognosis and unfavorable outcome.[3,4]

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<em>EGR1</em>/5p15 DNA Probes