Two Color, Enumeration Probe

Ref: 22-007

The EGFR/Cen7 DNA-FISH Probe is designed to detect an increase in copy number of the EGFR gene on 7p11 (previously assigned to band 7p12) relative to the control Cen7 probe using fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded (FPPE) tissues.[1]  The EGFR gene encodes a transmembrane protein involved in cell proliferation.[2,3]  Increased copy number of the EGFR gene has been reported in non-small cell lung cancer (NSCLC) cases and some other carcinomas such as colorectal, head and neck, and breast cancer cases.[3-6]  An increased EGFR copy number is predictive of response to anti-EGFR therapies.[1-5]

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<em>EGFR</em>/Cen7 DNA Probes