Two Color, Enumeration Probe

Ref: 11-007

The D7S486/Cen7 DNA-FISH Probe is designed to detect the deletion of the D7S486 locus located on 7q31 relative to the centromere 7 control locus, using fluorescence in situ hybridization (FISH). Deletions of chromosome 7 are frequently seen in many types of myeloid neoplasms. Loss of the D7S486 locus is detected in ~5% of adults with de novo myelodysplastic syndrome (MDS) and in ~50% of children with de novo MDS.[1]  Additionally, loss of the D7S486 locus is observed in 5% of de novo acute myeloid leukemia (AML) patients and in 30 – 40% of therapy related MDS (t-MDS)/AML (t-AML) patients.[1,2]  Deletion of the D7S486 locus or monosomy of chromosome 7 is associated with a poor prognosis in adults and children diagnosed with MDS and/or AML.[1,3]

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D7S486/Cen7 DNA Probes