Two Color, Enumeration Probe

Ref: 14-009

The D13S25/D13S1009 DNA-FISH Probe is designed to detect loss of the D13S25 locus on chromosome 13q14 relative to the control marker D13S1009 on chromosome 13q34 by fluorescence in situ hybridization (FISH).  The deletion of D13S25, a locus distal to the RB1 gene, has been detected in B-cell chronic lymphocytic leukemia (B-CLL),[1] in multiple myeloma (MM),[2,3] and rarely in a variety of non-Hodgkin lymphomas (NHL).[4]  Deletion of 13q14 has a strong prognostic value correlating with slower disease progression and better prognosis in B-CLL patients,[5] whereas in MM patients it is associated with a higher stage of disease and shorter survival.[6]

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D13S25/D13S1009 DNA Probes