Two Color, Two Fusion Translocation Probe

Ref: 14-006

The CCND1/IGH DNA-FISH Probe is designed to detect the translocation between the CCND1 gene located on 11q13 and the IGH gene located on 14q32 by fluorescence in situ hybridization (FISH).  The translocation between the CCND1 and IGH gene is designated as t(11;14)(q13;q32) and is the cytogenetic hallmark of mantle cell lymphoma (MCL), which distinguishes it from other non-Hodgkin lymphomas.[1,2]  The t(11;14) also has been detected in light chain amyloidosis, monoclonal gammopathy of undetermined significance  (MGUS), and multiple myeloma (MM) cases.[3,4]  The presence of t(11;14)(q13;q32) in MM patients is associated with an improved survival.[5]

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<em>CCND1</em>/<em>IGH</em> DNA Probes