BCL6 Break Apart

Two Color, Break Apart Probe

Ref: 18-010

The BCL6 Break Apart DNA-FISH Probe is designed to detect the translocations between the BCL6 gene located on 3q27 and one of at least 20 known translocation partner loci as detected by fluorescence in situ hybridization (FISH).  Translocation of the BCL6 gene occurs in 6-26% of follicular lymphoma (FL)[1]  with higher incidence (44%) in grade 3 cases negative for t(14;18)(q32;q21).[2]  Rearrangement of the BCL6 gene is observed at a frequency of 15~40% in diffuse large B-cell lymphomas (DLBCL).[1-3]

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<em>BCL6</em> Break Apart DNA Probes