ATM/D11S1251

Two Color, Enumeration Probe

Ref: 14-018

The ATM/D11S1251 DNA-FISH Probe is designed to detect the deletion of the ATM gene located on 11q22 relative to the control locus D11S1251 located on 11p15 by fluorescence in situ hybridization (FISH). ATM deletions are frequently seen in several types of hematologic malignancies. The deletion of the ATM gene is detected in ~65% of T-cell prolymphocytic leukemia (T-PLL) cases[1], ~50% of mantle cell lymphoma (MCL) cases[1,2], and ~20% of chronic lymphocytic leukemia (CLL) cases.[3]  Deletion of 11q in CLL patients is associated with extensive lymphadenopathy, disease progression, and shorter median survival.[3,4]  Significantly improved clinical outcomes in previously untreated CLL patients with ATM loss have been observed using alkylating agent-based chemo-immunotherapy regimens.[5]

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<em>ATM</em>/D11S1251 DNA Probes