Two Color, Two Fusion Translocation Probe

Ref: 21-001

The ALK/NPM1 DNA-FISH Probe is designed to detect the translocation between the ALK gene located at 2p23 and the NPM1 gene located at 5q35, using fluorescence in situ hybridization (FISH); the translocation between the ALK and NPM1 gene is designated as t(2;5)(p23;q35).  By conventional cytogenetics, the translocation occurs in up to 50% of anaplastic large cell lymphoma (ALCL) cases.[1]  As assessed by immunohistochemistry, expression of the fusion protein ALK/NPM1 that is generated by t(2;5), occurs more frequently in childhood ALCL with an occurance rate of 83% versus adult ALCL which has an occurance rate of 31%.[1,2]  The presence of t(2;5)(p23;q35) carries a better overall prognosis for ALCL patients.[1]

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<em>ALK</em>/<em>NPM1</em> DNA Probes