ALK Break Apart

Two Color, Break Apart Probe

Ref: 21-002

The ALK Break Apart DNA-FISH Probe is designed to detect the translocation between the ALK gene located at 2p23 and one of at least 14 known translocation partner loci using fluorescence in situ hybridization (FISH).[1]  Translocation of the ALK gene occurs in ~50% of anaplastic large cell lymphoma (ALCL) cases with a form of t(2;5)(p23;q35), as determined by conventional cytogenetics; in such cases, the presence of the t(2;5)(p23;q35) form carries a better overall prognosis for ALCL patients.[2]  ALK translocation has been observed in vesical inflammatory myofibroblastic tumors (IMT) of the bladder (>66%)[3] and serves as a diagnostic biomarker for differential diagnosis of IMT from sarcomatous lesions.[3]  ALK translocation is observed in ~5% – 16% of non-small cell lung cancer (NSCLC) cases in the form of inv(2)(p21p23), as determined by FISH,[4] and serves as a biomarker for therapy response.[4,5]  The presence of the ALK translocation in NSCLC patients is correlated with a marked sensitivity to pemetrexed and crizotinib treatment.[6]

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<em>ALK</em> Break Apart DNA Probes