5p15, 9q34, 15q24
Three Color, Enumeration Probe
Ref: 16-003
The 5p15, 9q34, 15q24 DNA-FISH Probe is designed to detect changes in copy number of chromosome(s) 5, 9, and 15 by fluorescence in situ hybridization (FISH). Hyperdiploidy is characterized by increased copy numbers of chromosomes such that the modal chromosomal number is 47-57.It is observed in 30-50% of multiple myeloma (MM) cases where the most common trisomies involve chromosomes 3, 5, 7, 9, 11, 15, 19, and 21.[1] In a diagnostic setting, gain of at least two of the three chromosomes 5, 9, or 15 in MM is considered an indicator for hyperdiploidy.[2] When assessed by G-banded karyotype and in the absence of other aberrations such as IGH translocations or deletion of chromosome 13, hyperdiploidy in MM is associated with a good prognosis.[3-5]
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